PERSPECTIVE
Can AI Say “I Don’t Know”?
Andrea Sikora, Leo A. Celi, Raja-Elie E. Abdulnour
N Engl J Med 2026;394:1873-1875
DOI: 10.1056/NEJMp2517624
I will not be ashamed to say “I know not.”
— Hippocratic Oath
A first-year resident is asked, “What explains the patient’s rising creatinine?” She pauses. “I don’t know ….” The team reviews the patient’s medications and risk factors and chooses a cautious...
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